The zinc-dependent major histocompatibility complex class II binding site of streptococcal pyrogenic exotoxin C is critical for maximal superantigen function and toxic activity.

نویسندگان

  • Timothy J Tripp
  • John K McCormick
  • Jennifer M Webb
  • Patrick M Schlievert
چکیده

The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the beta-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in dramatically reduced biological activities. Thus, the zinc-dependent major histocompatibility complex II binding site is critical for maximal biological function of SPE C.

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عنوان ژورنال:
  • Infection and immunity

دوره 71 3  شماره 

صفحات  -

تاریخ انتشار 2003